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dc.contributor.author Sin, Yung Wa
dc.contributor.author Annavi, Geetha
dc.contributor.author Newman, Chris
dc.contributor.author Buesching, Christina
dc.contributor.author Burke, Terry
dc.contributor.author Macdonald, David W.
dc.contributor.author Dugdale, Hannah L.
dc.coverage.spatial Wytham Woods
dc.coverage.spatial Oxfordshire
dc.coverage.spatial UK
dc.coverage.spatial 51°46’26N
dc.coverage.spatial 1°19’19W
dc.coverage.temporal Holocene
dc.date.accessioned 2015-04-28T14:51:41Z
dc.date.available 2015-04-28T14:51:41Z
dc.date.issued 2015-04-27
dc.identifier doi:10.5061/dryad.d8080
dc.identifier.citation Sin YW, Annavi G, Newman C, Buesching C, Burke T, Macdonald DW, Dugdale HL (2015) MHC class II assortative mate choice in European badgers (Meles meles). Molecular Ecology 24(12): 3138-3150.
dc.identifier.uri http://hdl.handle.net/10255/dryad.86094
dc.description The major histocompatibility complex (MHC) plays a crucial role in the immune system, and in some species, it is a target by which individuals choose mates to optimize the fitness of their offspring, potentially mediated by olfactory cues. Under the genetic compatibility hypothesis, individuals are predicted to choose mates with compatible MHC alleles, to increase the fitness of their offspring. Studies of MHC-based mate choice in wild mammals are under-represented currently, and few investigate more than one class of MHC genes. We investigated mate choice based on the compatibility of MHC class I and II genes in a wild population of European badgers (Meles meles). We also investigated mate choice based on microsatellite-derived pairwise relatedness, to attempt to distinguish MHC-specific effects from genomewide effects. We found MHC-assortative mating, based on MHC class II, but not class I genes. Parent pairs had smaller MHC class II DRB amino acid distances and smaller functional distances than expected from random pairings. When we separated the analyses into within-group and neighbouring-group parent pairs, only neighbouring-group pairs showed MHC-assortative mating, due to similarity at MHC class II loci. Our randomizations showed no evidence of genomewide-based inbreeding, based on 35 microsatellite loci; MHC class II similarity was therefore the apparent target of mate choice. We propose that MHC-assortative mate choice may be a local adaptation to endemic pathogens, and this assortative mate choice may have contributed to the low MHC genetic diversity in this population.
dc.relation.haspart doi:10.5061/dryad.d8080/1
dc.relation.haspart doi:10.5061/dryad.d8080/2
dc.relation.haspart doi:10.5061/dryad.d8080/3
dc.relation.haspart doi:10.5061/dryad.d8080/4
dc.relation.haspart doi:10.5061/dryad.d8080/5
dc.relation.haspart doi:10.5061/dryad.d8080/6
dc.relation.haspart doi:10.5061/dryad.d8080/7
dc.relation.haspart doi:10.5061/dryad.d8080/8
dc.relation.isreferencedby doi:10.1111/mec.13217
dc.relation.isreferencedby PMID:25913367
dc.subject Genetic compatibility hypothesis
dc.subject Major histocompatibility complex
dc.subject MHC-assortative mating
dc.subject pre- and post-copulatory mate choice
dc.subject sexual selection
dc.title Data from: MHC class II assortative mate choice in European badgers (Meles meles)
dc.type Article
dwc.ScientificName Meles meles
prism.publicationName Molecular Ecology

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Title candidate males (MHC class I)
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Title candidate males (MHC class II DRB)
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Title candidate males MHC class I genotypes
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Title candidate males MHC class II DRB genotypes
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Title microsatellite genotyping data
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Title neighboring social groups
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Title parent pairs MHC genotyping data (class I)
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Title parent pairs MHC genotyping data (class II DRB)
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Download parent pairs MHC genotyping data (class I...B).txt (7.001 Kb)
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